cyclization; enynals; komaroviquinone; natural products; total synthesis
Issue Date
2016-08
Publisher
WILEY-V C H VERLAG GMBH
Citation
ASIAN JOURNAL OF ORGANIC CHEMISTRY, v. 5, NO. 10, Page. 1237-1241
Abstract
A formal synthesis of komaroviquinone has been accomplished by utilizing the Pt-catalyzed hydrative cyclization of an enynal that was easily prepared in a convergent manner. The Pt-catalyzed hydrative cyclization reaction afforded the corresponding tricyclic product, which was utilized in the synthesis of a known precursor that led to the formation of komaroviquinone through an additional four-step synthesis.