Complex adaptive therapeutic strategy (CATS) for cancer
- Title
- Complex adaptive therapeutic strategy (CATS) for cancer
- Author
- 조용우
- Keywords
- Tumor heterogeneity; Complex adaptive system (CAS); Induced phenotype; Tumor network; Cancer immunotherapy; Nanoparticle
- Issue Date
- 2014-02
- Publisher
- ELSEVIER
- Citation
- JOURNAL OF CONTROLLED RELEASE, v. 175, Page. 43-47
- Abstract
- Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra-and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system(CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy. (C) 2013 Elsevier B.V. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0168365913009590?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/183747
- ISSN
- 0168-3659;1873-4995
- DOI
- 10.1016/j.jconrel.2013.12.017
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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