Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 조용우 | - |
dc.date.accessioned | 2023-07-17T01:14:38Z | - |
dc.date.available | 2023-07-17T01:14:38Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v. 175, Page. 43-47 | - |
dc.identifier.issn | 0168-3659;1873-4995 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0168365913009590?via%3Dihub | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/183747 | - |
dc.description.abstract | Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra-and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system(CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | Tumor heterogeneity | - |
dc.subject | Complex adaptive system (CAS) | - |
dc.subject | Induced phenotype | - |
dc.subject | Tumor network | - |
dc.subject | Cancer immunotherapy | - |
dc.subject | Nanoparticle | - |
dc.title | Complex adaptive therapeutic strategy (CATS) for cancer | - |
dc.type | Article | - |
dc.relation.volume | 175 | - |
dc.identifier.doi | 10.1016/j.jconrel.2013.12.017 | - |
dc.relation.page | 43-47 | - |
dc.relation.journal | JOURNAL OF CONTROLLED RELEASE | - |
dc.contributor.googleauthor | Cho, Yong Woo | - |
dc.contributor.googleauthor | Kim, Sang Yoon | - |
dc.contributor.googleauthor | Kwon, Ick Chan | - |
dc.contributor.googleauthor | Kim, In-San | - |
dc.sector.campus | E | - |
dc.sector.daehak | 공학대학 | - |
dc.sector.department | 재료화학공학과 | - |
dc.identifier.pid | ywcho7 | - |
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