Mycosporine-like amino acids (MAAs) 처리에 따른 배양세포 내 스크래피 프리온 단백질의 형성증가
- Title
- Mycosporine-like amino acids (MAAs) 처리에 따른 배양세포 내 스크래피 프리온 단백질의 형성증가
- Other Titles
- Enhanced formation of scrapie prion protein in cultured ceils by treatment with mycosporine-like amino acids (MAAs)
- Author
- 류종석
- Keywords
- Mycosporine-like amino acids; Prion; Protein aggregation; PrP
- Issue Date
- 2015-06
- Publisher
- Korean Society for Microbiolog and Biotechnology
- Citation
- Korean Journal of Microbiology and Biotechnology, v. 43, NO. 2, Page. 91.0-96.0
- Abstract
- Prions are proteinaceous infectious particles that cause neurodegenerative diseases, such as scrapie in sheep, bovine spongiform encephalopathy in cattle and Creutzfeldt-Jakob disease (CJD) in humans. Although the detailed process, regarding the abnormal conversion of prion proteins (PrP), remains to be fully elucidated, a number of environmental factors appear to affect the formation of misfolded PrP, termed PrPSc. Because oceanic algae contain mycosporine-like amino acids (MAAs), which exhibit cellular defensive activities under a variety of stress conditions, we investigated the level of PrPSc in prion-infected neuroblastoma cells using mycosporine-glycine, porphyra-334 and shinorine. When judged by the level of protease-resistant PrPSc in western blots, porphyra-334 and shinorine increased the level of PrPSc in cells, but mycosporine-glycine did not. The current results indicate that the MAAs tested in this study enhance the formation of PrPSc. © 2015, The Korean Society for Microbiology and Biotechnology.
- URI
- https://www.mbl.or.kr/journal/view.html?doi=10.4014/mbl.1503.03002https://repository.hanyang.ac.kr/handle/20.500.11754/180549
- ISSN
- 1598-642X
- DOI
- 10.4014/mbl.1503.03002
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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