Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 류종석 | - |
dc.date.accessioned | 2023-05-17T00:58:56Z | - |
dc.date.available | 2023-05-17T00:58:56Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | Korean Journal of Microbiology and Biotechnology, v. 43, NO. 2, Page. 91.0-96.0 | - |
dc.identifier.issn | 1598-642X | - |
dc.identifier.uri | https://www.mbl.or.kr/journal/view.html?doi=10.4014/mbl.1503.03002 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/180549 | - |
dc.description.abstract | Prions are proteinaceous infectious particles that cause neurodegenerative diseases, such as scrapie in sheep, bovine spongiform encephalopathy in cattle and Creutzfeldt-Jakob disease (CJD) in humans. Although the detailed process, regarding the abnormal conversion of prion proteins (PrP), remains to be fully elucidated, a number of environmental factors appear to affect the formation of misfolded PrP, termed PrPSc. Because oceanic algae contain mycosporine-like amino acids (MAAs), which exhibit cellular defensive activities under a variety of stress conditions, we investigated the level of PrPSc in prion-infected neuroblastoma cells using mycosporine-glycine, porphyra-334 and shinorine. When judged by the level of protease-resistant PrPSc in western blots, porphyra-334 and shinorine increased the level of PrPSc in cells, but mycosporine-glycine did not. The current results indicate that the MAAs tested in this study enhance the formation of PrPSc. © 2015, The Korean Society for Microbiology and Biotechnology. | - |
dc.description.sponsorship | Ministry of Education 2013R1A1A2011210 | - |
dc.language | ko | - |
dc.publisher | Korean Society for Microbiolog and Biotechnology | - |
dc.subject | Mycosporine-like amino acids | - |
dc.subject | Prion | - |
dc.subject | Protein aggregation | - |
dc.subject | PrP | - |
dc.title | Mycosporine-like amino acids (MAAs) 처리에 따른 배양세포 내 스크래피 프리온 단백질의 형성증가 | - |
dc.title.alternative | Enhanced formation of scrapie prion protein in cultured ceils by treatment with mycosporine-like amino acids (MAAs) | - |
dc.type | Article | - |
dc.relation.no | 2 | - |
dc.relation.volume | 43 | - |
dc.identifier.doi | 10.4014/mbl.1503.03002 | - |
dc.relation.page | 91.0-96.0 | - |
dc.relation.journal | Korean Journal of Microbiology and Biotechnology | - |
dc.contributor.googleauthor | Lee, J. | - |
dc.contributor.googleauthor | Moh, S.-H. | - |
dc.contributor.googleauthor | Ryou, C. | - |
dc.contributor.googleauthor | Kim, D.-H. | - |
dc.sector.campus | E | - |
dc.sector.daehak | 약학대학 | - |
dc.sector.department | 약학과 | - |
dc.identifier.pid | cryou2 | - |
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