Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy
- Title
- Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy
- Author
- 이준석
- Keywords
- bacteriolytic therapy; nano–bio emulsions; scintillating nanoparticles; tu-mor microenvironments; X-ray photodynamic therapy (PDT)
- Issue Date
- 2020-06
- Publisher
- WILEY
- Citation
- ADVANCED HEALTHCARE MATERIALS, v. 9, no. 13, article no. 1901812
- Abstract
- Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobicClostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4:Tb,Ce@NaGdF(4)core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) andC. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobicC. novyi-NT spores in the tumor site, is confirmed by both X-ray andT(1)-weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobicC. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy.
- URI
- https://onlinelibrary.wiley.com/doi/10.1002/adhm.201901812https://repository.hanyang.ac.kr/handle/20.500.11754/168701
- ISSN
- 2192-2640; 2192-2659
- DOI
- 10.1002/adhm.201901812
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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