Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이준석 | - |
dc.date.accessioned | 2022-02-28T07:53:42Z | - |
dc.date.available | 2022-02-28T07:53:42Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.citation | ADVANCED HEALTHCARE MATERIALS, v. 9, no. 13, article no. 1901812 | en_US |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.issn | 2192-2659 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/adhm.201901812 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/168701 | - |
dc.description.abstract | Various cancer therapies have been developed, but tumor recurrence with incomplete tumor killing and remaining tumor cells/tissues is frequent in monotherapies. Herein, a nano-bio therapeutic emulsion formulated with multifunctional nanoscintillators and anaerobicClostridium novyi-NT spores for synergistic image-guided combinational cancer therapy is reported. MRI visible nanoscintillators (NSs) are synthesized with a NaGdF4:Tb,Ce@NaGdF(4)core/shell structure for an image-guided X-ray photodynamic therapy (PDT) of the normoxic peripheral tumor. An anaerobic oncolytic bacterium (C. novyi-NT) therapy is combined to treat the hypoxic central tumor tissues. Photosensitizer-coated NSs (PS-NSs) andC. novyi-NT spores are emulsified with clinically available ethiodized oil (Lipiodol) to be the nano-bio therapeutic emulsion and injected into the tumor with computed tomography image guidance. The distribution of nano-bio therapeutic emulsion, including PS-NSs and anaerobicC. novyi-NT spores in the tumor site, is confirmed by both X-ray andT(1)-weighted magnetic resonance imaging. Following the image-guided X-ray PDT and anaerobicC. novyi- NT combination treatment, apoptotic cell death in cancer tissues, including both peripheral and central tumor regions, is significantly higher than in the control groups. This combination therapy approach using a nano-bio therapeutic emulsion is expected to overcome the limitations of conventional cancer therapy, resulting in increased cancer-therapeutic efficacy. | en_US |
dc.description.sponsorship | This work was supported by grants R01CA218659 and R01EB026207 from the National Cancer Institute and National Institute of Biomedical Imaging and Bioengineering and a grant from the Korea Institute of Science and Technology Institutional Program (2E29290/CAP-16-02-KIST), and the Basic Science Research Program (2018R1C1B6001120) through the National Research Foundation of Korea funded by the Ministry of Science and ICT (MSIT). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY | en_US |
dc.subject | bacteriolytic therapy | en_US |
dc.subject | nano–bio emulsions | en_US |
dc.subject | scintillating nanoparticles | en_US |
dc.subject | tu-mor microenvironments | en_US |
dc.subject | X-ray photodynamic therapy (PDT) | en_US |
dc.title | Tumor Microenvironment Targeting Nano-Bio Emulsion for Synergistic Combinational X-Ray PDT with Oncolytic Bacteria Therapy | en_US |
dc.type | Article | en_US |
dc.relation.no | 13 | - |
dc.relation.volume | 9 | - |
dc.identifier.doi | 10.1002/adhm.201901812 | - |
dc.relation.page | 1-8 | - |
dc.relation.journal | ADVANCED HEALTHCARE MATERIALS | - |
dc.contributor.googleauthor | Park, Wooram | - |
dc.contributor.googleauthor | Cho, Soojeong | - |
dc.contributor.googleauthor | Kang, Dongkyu | - |
dc.contributor.googleauthor | Han, Jun-Hyeok | - |
dc.contributor.googleauthor | Park, Jung-Hoon | - |
dc.contributor.googleauthor | Lee, Byeongdu | - |
dc.contributor.googleauthor | Lee, Joonseok | - |
dc.contributor.googleauthor | Kim, Dong-Hyun | - |
dc.relation.code | 2020049014 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF CHEMISTRY | - |
dc.identifier.pid | joonseoklee | - |
dc.identifier.researcherID | AAP-6003-2021 | - |
dc.identifier.orcid | https://orcid.org/0000-0001-9551-6402 | - |
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