Microwave를 이용한 1,3,5-Trisubstituted-1,2,4-triazoles의 합성 및 카르보고리 Pyrrolo[2,3-d]pyrimidine 뉴클레오사이드 유사체의 합성 연구

Abstract

Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted-1,2,4-triazoles from benzamides can also be accomplished in a simple one-pot sequential reaction.|New carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs have been described from the key intermediate 2. The key intermediate was reacted with cyclopentyl bromide, followed by oxidative hydrolysis to afford the two regioisomers which are 1-substituted and 7-substituted compound. Cytotoxicity evaluation resulted that 1-substituted compound inhibited the cell growth of human ovarian cancer cells. We also synthesized other carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs that are related to 1-substituted compound by Pd(0)-catalyzed coupling reaction for structure and activity relationship study.; New carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs have been described from the key intermediate 2. The key intermediate was reacted with cyclopentyl bromide, followed by oxidative hydrolysis to afford the two regioisomers which are 1-substituted and 7-substituted compound. Cytotoxicity evaluation resulted that 1-substituted compound inhibited the cell growth of human ovarian cancer cells. We also synthesized other carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs that are related to 1-substituted compound by Pd(0)-catalyzed coupling reaction for structure and activity relationship study.