Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이학준 | - |
dc.contributor.author | 이종복 | - |
dc.date.accessioned | 2020-03-17T16:55:32Z | - |
dc.date.available | 2020-03-17T16:55:32Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/137330 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000418392 | en_US |
dc.description.abstract | Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted-1,2,4-triazoles from benzamides can also be accomplished in a simple one-pot sequential reaction.|New carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs have been described from the key intermediate 2. The key intermediate was reacted with cyclopentyl bromide, followed by oxidative hydrolysis to afford the two regioisomers which are 1-substituted and 7-substituted compound. Cytotoxicity evaluation resulted that 1-substituted compound inhibited the cell growth of human ovarian cancer cells. We also synthesized other carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs that are related to 1-substituted compound by Pd(0)-catalyzed coupling reaction for structure and activity relationship study.; New carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs have been described from the key intermediate 2. The key intermediate was reacted with cyclopentyl bromide, followed by oxidative hydrolysis to afford the two regioisomers which are 1-substituted and 7-substituted compound. Cytotoxicity evaluation resulted that 1-substituted compound inhibited the cell growth of human ovarian cancer cells. We also synthesized other carbocyclic pyrrolo[2,3-d]pyrimidine nucleoside analogs that are related to 1-substituted compound by Pd(0)-catalyzed coupling reaction for structure and activity relationship study. | - |
dc.publisher | 한양대학교 | - |
dc.title | Microwave를 이용한 1,3,5-Trisubstituted-1,2,4-triazoles의 합성 및 카르보고리 Pyrrolo[2,3-d]pyrimidine 뉴클레오사이드 유사체의 합성 연구 | - |
dc.title.alternative | The Synthesis of 1,3,5-Trisubstituted-1,2,4-triazoles by Microwave-assisted Reaction and The Synthesis of Carbocyclic Pyrrolo[2,3-d]pyrimidine Nucleoside Analogs | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 이종복 | - |
dc.contributor.alternativeauthor | Jongbok Lee | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 바이오나노학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 나노공학, 유기합성 | - |
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