Gold-catalyzed tandem reaction of 2-alkynylanilines followed by 1,6-conjugate addition to p-quinone methides: efficient access to unsymmetrical diarylindolylmethanes
- Title
- Gold-catalyzed tandem reaction of 2-alkynylanilines followed by 1,6-conjugate addition to p-quinone methides: efficient access to unsymmetrical diarylindolylmethanes
- Author
- 오창호
- Keywords
- CROSS-COUPLING REACTIONS; ELECTROPHILIC CYCLIZATION; SEQUENTIAL ARYLATION; O-ALKYNYLANILINES; TRIARYLMETHANES; INDOLES; DERIVATIVES; ALDEHYDES; AGENTS; BIS(INDOLYL)METHANES
- Issue Date
- 2018-09
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NEW JOURNAL OF CHEMISTRY, v. 42, no. 20, page. 16886-16890
- Abstract
- A simple, mild, efficient and chemoselective catalytic method for the straightforward synthesis of an interesting class of 2-aryl/alkyl-substituted-3-diaryl indolyl methanes in high yield is reported. This atom-efficient method proceeds via a gold-catalyzed one-pot sequential intramolecular hydroamination (C-N bond formation) of 2-alkynylanilines followed by a 1,6-conjugate addition to p-quinonemethides. The p-quinonemethides, which contain aldehyde functional groups, preferentially participate in 1,6-conjugate addition, while the aldehyde functional group remains unreactive.
- URI
- https://pubs.rsc.org/en/content/articlelanding/2018/NJ/C8NJ03955K#!divAbstracthttps://repository.hanyang.ac.kr/handle/20.500.11754/120006
- ISSN
- 1144-0546; 1369-9261
- DOI
- 10.1039/c8nj03955k
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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