Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
- Title
- Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
- Author
- 이종민
- Keywords
- cognition; cortical thickness; early stage; late stage; subcortical vascular mild cognitive impairment
- Issue Date
- 2018-02
- Publisher
- WILEY
- Citation
- EUROPEAN JOURNAL OF NEUROLOGY, v. 25, no. 2, page. 326-333
- Abstract
- Background and purpose Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.Methods Seventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [C-11] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.Results There was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI.Conclusions We suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI.
- URI
- https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13500https://repository.hanyang.ac.kr/handle/20.500.11754/117613
- ISSN
- 1351-5101; 1468-1331
- DOI
- 10.1111/ene.13500
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML