Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2019-12-05T15:53:03Z | - |
dc.date.available | 2019-12-05T15:53:03Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF NEUROLOGY, v. 25, no. 2, page. 326-333 | en_US |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.issn | 1468-1331 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13500 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/117613 | - |
dc.description.abstract | Background and purpose Biomarker changes in cognitively impaired patients with small vessel disease are largely unknown. The rate of amyloid/lacune progression, cortical thinning and cognitive decline were evaluated in subcortical vascular mild cognitive impairment (svMCI) patients.Methods Seventy-two svMCI patients were divided into early stage (ES-svMCI, n = 39) and late stage (LS-svMCI, n = 33) according to their Clinical Dementia Rating Sum of Boxes score. Patients were annually followed up with neuropsychological tests and brain magnetic resonance imaging for 3 years, and underwent a second [C-11] Pittsburgh compound B (PiB) positron emission tomography scan within a mean interval of 32.4 months.Results There was no difference in the rate of increase in PiB uptake or lacune number between the ES-svMCI and LS-svMCI. However, LS-svMCI showed more rapid cortical thinning and cognitive decline than did the ES-svMCI.Conclusions We suggest that, whilst the rate of change in pathological burden did not differ between ES-svMCI and LS-svMCI, cortical thinning and cognitive decline progressed more rapidly in the LS-svMCI. | en_US |
dc.description.sponsorship | This research was supported by National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2015R1C1A2A01053281); the Original Technology Research Program for Brain Science through the NRF funded by the Korean government (MSIP) (2014M3C7A1064752); the NRF grant funded by the Korea government (MSIP) (NRF-2017R1A2B2005081); the Korea Ministry of Environment (MOE) as the Environmental Health Action Program (1485014533); and the Brain Research Program through the NRF of Korea funded by the MSIP (2016M3C7A1913844). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY | en_US |
dc.subject | cognition | en_US |
dc.subject | cortical thickness | en_US |
dc.subject | early stage | en_US |
dc.subject | late stage | en_US |
dc.subject | subcortical vascular mild cognitive impairment | en_US |
dc.title | Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 25 | - |
dc.identifier.doi | 10.1111/ene.13500 | - |
dc.relation.page | 326-333 | - |
dc.relation.journal | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.contributor.googleauthor | Lee, J. | - |
dc.contributor.googleauthor | Seo, S. W. | - |
dc.contributor.googleauthor | Yang, J. -J. | - |
dc.contributor.googleauthor | Jang, Y. K. | - |
dc.contributor.googleauthor | Lee, J. S. | - |
dc.contributor.googleauthor | Kim, Y. J. | - |
dc.contributor.googleauthor | Chin, J. | - |
dc.contributor.googleauthor | Lee, J. M. | - |
dc.contributor.googleauthor | Kim, S. T. | - |
dc.contributor.googleauthor | Lee, K. -H. | - |
dc.relation.code | 2018005071 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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