Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells
- Title
- Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells
- Author
- 오성근
- Keywords
- Adeno-associated virus; Pro-apoptotic gene; Gene delivery system; Melanoma; [6]-Gingerol
- Issue Date
- 2017-07
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- NEW BIOTECHNOLOGY, v. 37, page. 194-199
- Abstract
- We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies. (C) 2017 Elsevier B.V. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S187167841632369X?via%3Dihubhttps://repository.hanyang.ac.kr/handle/20.500.11754/114775
- ISSN
- 1871-6784; 1876-4347
- DOI
- 10.1016/j.nbt.2017.02.001
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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