Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오성근 | - |
dc.date.accessioned | 2019-11-26T07:42:09Z | - |
dc.date.available | 2019-11-26T07:42:09Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.citation | NEW BIOTECHNOLOGY, v. 37, page. 194-199 | en_US |
dc.identifier.issn | 1871-6784 | - |
dc.identifier.issn | 1876-4347 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S187167841632369X?via%3Dihub | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/114775 | - |
dc.description.abstract | We exploited the emerging potential of gene therapy strategies to design a powerful therapeutic system that combines two key components AAV vector and [6]-gingerol. In this study, we created an AAV2 construct expressing the proapoptotic protein BIM, which uses HSPG as its primary receptor, to target HSPG-overexpressing melanoma cells. This combination treatment showed promising results in vitro, inducing apoptosis in human melanoma cells. This new platform technology will make a significant contribution to numerous therapeutic applications, most notably for melanoma, including overcoming resistance to conventional anticancer therapies. (C) 2017 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | We thank Professor Kim Taewoo in Korea University for providing melanoma cells. This work was supported by the Bio & Medical Technology Development Program (NRF-2013M3A9D3046431) funded by the Ministry of Science, ICT & Future Planning (MSIP) and supported by the AMOREPACIFIC Corporation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Adeno-associated virus | en_US |
dc.subject | Pro-apoptotic gene | en_US |
dc.subject | Gene delivery system | en_US |
dc.subject | Melanoma | en_US |
dc.subject | [6]-Gingerol | en_US |
dc.title | Development of efficient adeno-associated virus (AAV)-mediated gene delivery system with a phytoactive material for targeting human melanoma cells | en_US |
dc.type | Article | en_US |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1016/j.nbt.2017.02.001 | - |
dc.relation.page | 194-199 | - |
dc.relation.journal | NEW BIOTECHNOLOGY | - |
dc.contributor.googleauthor | Lee, John Hwan | - |
dc.contributor.googleauthor | Kim, Yoojin | - |
dc.contributor.googleauthor | Yoon, Ye-Eun | - |
dc.contributor.googleauthor | Kim, Yong-Jin | - |
dc.contributor.googleauthor | Oh, Seong-Geun | - |
dc.contributor.googleauthor | Jang, Jae-Hyung | - |
dc.contributor.googleauthor | Kim, Eunmi | - |
dc.relation.code | 2017000260 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL ENGINEERING | - |
dc.identifier.pid | seongoh | - |
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