Noninvasive Visualization of Enhanced Transdermal Delivery Using Skin-Adhesive Polymeric Nanovehicles
- Title
- Noninvasive Visualization of Enhanced Transdermal Delivery Using Skin-Adhesive Polymeric Nanovehicles
- Other Titles
- 피부 접착성 고분자 나노연질전달체를 이용한 비침습 경피약물전달 증진 연구
- Author
- Hong, Sungjun
- Alternative Author(s)
- 홍성준
- Advisor(s)
- 김진웅
- Issue Date
- 2019-02
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- A transdermal delivery system based on skin-adhesive deformable polymeric nanovehicles (PNVs) that provides remarkably enhanced drug delivery efficiency is reported. Core-phase deformable skin-adhesive PNVs were fabricated through co-assembly of two amphiphilic triblock copolymers, poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(ethylene oxide) (PEO-b-PCL-b-PEO) and poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-b-PPO-b-PEO). The deformability of the PNV cores was tuned successfully, while maintaining the particle size at ~110 nm, by incorporation of PEO-b-PPO-b-PEO into the PNVs to a volume fraction of 0.3. Through an ex vivo skin penetration test, we showed that transactivator of transcription (TAT)-decorated deformable PNVs could not only exert strong adhesion to skin but also increase cellular uptake, leading to a transdermal delivery efficiency that is twice that of a hard PNV control. Moreover, noninvasive visualization of a fluorescent drug probe in the skin via confocal laser scanning microscopy analysis showed that the skin adhesiveness and deformability of the PNVs contributed directly to the enhancement of transdermal delivery.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/100409http://hanyang.dcollection.net/common/orgView/200000434642
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Theses (Master)
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