Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김진웅 | - |
dc.contributor.author | Hong, Sungjun | - |
dc.date.accessioned | 2019-02-28T03:25:13Z | - |
dc.date.available | 2019-02-28T03:25:13Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/100409 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000434642 | en_US |
dc.description.abstract | A transdermal delivery system based on skin-adhesive deformable polymeric nanovehicles (PNVs) that provides remarkably enhanced drug delivery efficiency is reported. Core-phase deformable skin-adhesive PNVs were fabricated through co-assembly of two amphiphilic triblock copolymers, poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(ethylene oxide) (PEO-b-PCL-b-PEO) and poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-b-PPO-b-PEO). The deformability of the PNV cores was tuned successfully, while maintaining the particle size at ~110 nm, by incorporation of PEO-b-PPO-b-PEO into the PNVs to a volume fraction of 0.3. Through an ex vivo skin penetration test, we showed that transactivator of transcription (TAT)-decorated deformable PNVs could not only exert strong adhesion to skin but also increase cellular uptake, leading to a transdermal delivery efficiency that is twice that of a hard PNV control. Moreover, noninvasive visualization of a fluorescent drug probe in the skin via confocal laser scanning microscopy analysis showed that the skin adhesiveness and deformability of the PNVs contributed directly to the enhancement of transdermal delivery. | - |
dc.publisher | 한양대학교 | - |
dc.title | Noninvasive Visualization of Enhanced Transdermal Delivery Using Skin-Adhesive Polymeric Nanovehicles | - |
dc.title.alternative | 피부 접착성 고분자 나노연질전달체를 이용한 비침습 경피약물전달 증진 연구 | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 홍성준 | - |
dc.contributor.alternativeauthor | 홍성준 | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 바이오나노학과 | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 바이오나노공학 | - |
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