Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis.
- Title
- Usefulness of spleen volume measured by computed tomography for predicting clinical outcome in primary myelofibrosis.
- Author
- 송무곤
- Keywords
- Primary myelofibrosis; Splenomegaly; Computed tomography; Splenic volume; Overall survival
- Issue Date
- 2016-10
- Publisher
- SPRINGER JAPAN KK
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v. 104, no. 4, page. 476-484
- Abstract
- Although splenomegaly is major characteristic of primary myelofibrosis (PMF), splenomegaly has been devalued due to a less reliable method based on physical examination (PEx). We evaluated whether spleen volume (SV) on CT would accurately predict clinical outcomes in PMF. A total of 188 patients were enrolled. SV was quantitated by the automatic volume software. In ROC curve, the SV predicted prognosis more accurately than spleen length by PEx (p < 0.001). The ideal cut-off value was 378.1 cm(3) for SV, which was divided into high- and low-volume status. Patients with low SV status had superior leukemia-free survival and overall survival compared to high SV status (p < 0.001, p < 0.001) In the Cox analysis, old age aeyen65 years (p = 0.004, p = 0.001), low Hemoglobin < 10.0 g/dL (p = 0.023, p = 0.021), high WBC counts aeyen25 x 10(9)/L (p = 0.003, p = 0.006), peripheral blasts aeyen1 % (p = 0.029, p = 0.020), unfavorable cytogenetic abnormalities (p = 0.025, p = 0.028), and high SV status (p = 0.004, p = 0.003) were independently associated with survivals. SV measured by CT was important for predicting survival in patients with PMF.
- URI
- https://link.springer.com/article/10.1007%2Fs12185-016-2050-yhttps://repository.hanyang.ac.kr/handle/20.500.11754/99073
- ISSN
- 0925-5710; 1865-3774
- DOI
- 10.1007/s12185-016-2050-y
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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