ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.
- Title
- ZIFIBI: Prediction of DNA binding sites for zinc finger proteins.
- Author
- 이영식
- Keywords
- C2H2 zinc finger protein; cis-regulatory region; transcription factor; hidden markov model; transcription factor binding site
- Issue Date
- 2008-04
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v. 369, No. 3, Page. 845-848
- Abstract
- The cis-regulatory region of target genes is key elements in the transcriptional regulation of gene expression. Many of these cis-regulatory regions have not been identified by either biological experiments or computational methods. Recently, a few additional C2H2 zinc finger transcription factor binding sites have been discovered. The majority of the zinc finger binding sites, however, are still unknown. In this study, we used publically available data to evaluate possible interaction patterns between nucleotides and the amino acids of zinc finger domains. We calculated the most probable state path of three nucleotides sequences using a Hidden Markov Model (HMM). We used these computations to predict C2H2 zinc finger transcription factor binding sites in cis-regulatory regions of their target genes (http://bioinfo.hanyang.ac.kr/ZIFIBI/frameset.php). (c) 2008 Elsevier Inc. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0006291X08003823https://repository.hanyang.ac.kr/handle/20.500.11754/80279
- ISSN
- 0006-291X
- DOI
- 10.1016/j.bbrc.2008.02.106
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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