Intramolecular Fischer Indole Synthesis for the Direct Synthesis of 3,4-Fused Tricyclic Indole and Application to the Total Synthesis of (-)-Aurantioclavine
- Title
- Intramolecular Fischer Indole Synthesis for the Direct Synthesis of 3,4-Fused Tricyclic Indole and Application to the Total Synthesis of (-)-Aurantioclavine
- Author
- 조천규
- Keywords
- (-)-N-METHYLWELWITINDOLINONE C ISONITRILE; ALLYLIC AMINATION; (+/-)-WELWITINDOLINONE-A ISONITRILE; (-)-COMMUNESIN F; ALKALOIDS; (+/-)-AURANTIOCLAVINE; HYDROARYLATION; COMBINATION; ANNULATION; ALCOHOLS
- Issue Date
- 2016-09
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v. 18, NO. 19, Page. 5098-5101
- Abstract
- Aryl hydrazides with a ketone or aldehyde containing side chains linked to the meta-position of the aromatic ring undergo acid-promoted intramolecular Fischer indole synthesis to generate 3,4-fused tricyclic indoles. The preparative utility of this conceptually new synthetic approach, which does not require prefunctionalization of the indole ring, was demonstrated by its application to a concise total synthesis of (-)-aurantioclavine.
- URI
- https://pubs.acs.org/doi/10.1021/acs.orglett.6b02541https://repository.hanyang.ac.kr/handle/20.500.11754/76866
- ISSN
- 1523-7060; 1523-7052
- DOI
- 10.1021/acs.orglett.6b02541
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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