Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration
- Title
- Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration
- Author
- 류종석
- Keywords
- Lipid nanoparticles; docetaxel; sustained release; pharmacokinetics; bioavailability; CONTROLLED DRUG-DELIVERY; IN-VIVO EVALUATION; ANTICANCER DRUGS; TUMOR MICROENVIRONMENT; VITRO; CYTOTOXICITY; NANOCARRIERS; CARRIERS; SYSTEMS; SLN
- Issue Date
- 2017-05
- Publisher
- TAYLOR & FRANCIS LTD
- Citation
- JOURNAL OF MICROENCAPSULATION, v. 34, No. 3, Page. 250-261
- Abstract
- The aim of this study was to develop docetaxel-incorporated lipid nanoparticles (DTX-NPs) to improve the pharmacokinetic behaviour of docetaxel (DTX) after oral and parenteral administration via sustained release. DTX-NPs were prepared by nanotemplate engineering technique with palmityl alcohol as a solid lipid and Tween-40/Span-40/Myrj S40 as a surfactants mixture. Spherical DTX-NPs below 100 nm were successfully prepared with a narrow particle size distribution, 96% of incorporation efficiency and 686 times increase in DTX solubility. DTX-NPs showed a sustained release over 24 h in phosphate-buffered saline and simulated gastric and intestinal fluids, while DTX-micelles released DTX completely within 12 h. The half-maximal inhibitory concentration (IC50) of DTX-NPs against human breast cancer MCF-7 cells was 1.9 times lower than that of DTX-micelles and DTX solution. DTX-NPs demonstrated 3.7- and 2.8-fold increase in the area under the plasma concentration-time curve compared with DTX-micelles after oral and parenteral administration, respectively.
- URI
- https://www.tandfonline.com/doi/abs/10.1080/02652048.2017.1337247https://repository.hanyang.ac.kr/handle/20.500.11754/72053
- ISSN
- 0265-2048; 1464-5246
- DOI
- 10.1080/02652048.2017.1337247
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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