Placental and lactational transfer of decabromodiphenyl ether and 2,2',4,4'-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats
- Title
- Placental and lactational transfer of decabromodiphenyl ether and 2,2',4,4'-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats
- Author
- 문효방
- Keywords
- 2,2',4,4'-tetrabromodiphenyl ether (BDE 47); 2,2',3,3',4,4',5,5',6,6'-decabromodiphenyl ether (BDE 209); Placental transfer; Lactational transfer; Sprague-Dawley rat; POLYBROMINATED DIPHENYL ETHERS; BREAST-MILK; FLAME RETARDANTS; DIETARY EXPOSURE; MATERNAL SERUM; MOTHERS MILK; SOUTH CHINA; CORD BLOOD; HOUSE-DUST; PBDES
- Issue Date
- 2017-04
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v. 102, Page. 198-203
- Abstract
- Although several studies have conducted maternal transfer of individual PBDE congener in experimental animals, there is a paucity of research on differences in maternal transfer of PBDE congeners. The purpose of the study was to investigate and compare placental and lactational transfer of BDE 47, -209 and its metabolites in rat dam-offspring pairs following repeated administration of BDE 47 and -209.C-13-BDE 47, BDE 209 and its debrominated congeners were detected both in dam serum and offspring body, which indicates that PBDEs can be maternally transferred. In addition, BDE 196 and -197 appeared in offspring body earlier than in maternal serum, which suggests that debromination can be occur in offspring body. BDE 209 increased in both dam and offspring while levels of C-13-BDE 47 was not increased in dam serum. 13C-BDE 47 seems to be stored in breast milk rather than in maternal serum, which can be assumed through the drastic increase of the congener in suckling pups. The magnitude of lactational transfer of the administered congeners was greater than that of placental transfer. And C-13-BDE 47 was relatively more transferred to suckling pups than BDE 209 through breastfeeding. (C) 2017 Elsevier Ltd. All rights reserved.
- URI
- https://www.sciencedirect.com/science/article/pii/S0278691517300352https://repository.hanyang.ac.kr/handle/20.500.11754/72016
- ISSN
- 0278-6915; 1873-6351
- DOI
- 10.1016/j.fct.2017.01.027
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
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