Controlled drug delivery from mesoporous silica using a pH-response release system
- Title
- Controlled drug delivery from mesoporous silica using a pH-response release system
- Author
- Justyn Wayne Jaworski
- Keywords
- SENSITIVE LIPOSOMES; POLYMERIC MICELLES; NANOPARTICLES; CURCUMIN; THERAPEUTICS; ORGANOSILICA; NANOSPHERES; HYDROGELS; VESICLES; CARRIERS
- Issue Date
- 2012-06
- Publisher
- Royal Society of Chemistry
- Citation
- NEW JOURNAL OF CHEMISTRY,Vol.36 No.8 [2012],p1616-162
- Abstract
- Mesoporous hollow silica nanoparticles were functionalized with phenanthroline (P-MHS) to prepare a carrier for a host-guest complex. Curcumin was selected as a model drug molecule. The phenanthroline attached to the P-MHS was complexed with Cu2+ through a coordination bond. When the Cu2+-P-MHS was exposed to similar to pH 5, the curcumin was efficiently released into the aqueous phase within 120 min. This work describes a method for functionalizing the surface of the porous silica nanoparticles in a well-defined manner. The P-MHS carrier exhibited controlled release of a model drug under acidic pH conditions.
- URI
- http://pubs.rsc.org/en/Content/ArticleLanding/2012/NJ/c2nj20976d#!divAbstracthttp://hdl.handle.net/20.500.11754/40154
- ISSN
- 1144-0546
- DOI
- 10.1039/c2nj20976d
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CHEMICAL ENGINEERING(화학공학과) > Articles
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