Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유홍기 | - |
dc.date.accessioned | 2018-02-08T00:35:54Z | - |
dc.date.available | 2018-02-08T00:35:54Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v. 6, NO 22608, Page. 1-11 | en_US |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://www.nature.com/articles/srep22608 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36039 | - |
dc.description.abstract | Macrophages mediate atheroma expansion and disruption, and denote high-risk arterial plaques. Therefore, they are substantially gaining importance as a diagnostic imaging target for the detection of rupture-prone plaques. Here, we developed an injectable near-infrared fluorescence (NIRF) probe by chemically conjugating thiolated glycol chitosan with cholesteryl chloroformate, NIRF dye (cyanine 5.5 or 7), and maleimide-polyethylene glycol-mannose as mannose receptor binding ligands to specifically target a subset of macrophages abundant in high-risk plaques. This probe showed high affinity to mannose receptors, low toxicity, and allowed the direct visualization of plaque macrophages in murine carotid atheroma. After the scale-up of the MMR-NIRF probe, the administration of the probe facilitated in vivo intravascular imaging of plaque inflammation in coronary-sized vessels of atheromatous rabbits using a custom-built dual-modal optical coherence tomography (OCT)-NIRF catheter-based imaging system. This novel imaging approach represents a potential imaging strategy enabling the identification of high-risk plaques in vivo and holds promise for future clinical implications. | en_US |
dc.description.sponsorship | We thank Young-Duk Kim, PhD, for assistance with intravital microscopy, and Ji Woong Kim for the illustrations of animals. This research was supported in part by a grant through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (No. 2015R1A2A2A07027863 to Drs. Kim, Park and Yoo, No. 2015R1A1A1A05027209 to Dr. Yoo, No. 2010-0017465 to Dr. Oh, No. 2014R1A2A1A10050330 to Dr. Gweon), the Ministry of Health & Welfare of Korea (HI15C0001) to Dr. Oh. | en_US |
dc.language.iso | en | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.subject | HUMAN ATHEROSCLEROTIC PLAQUES | en_US |
dc.subject | MATRIX METALLOPROTEINASES | en_US |
dc.subject | CORONARY-DISEASE | en_US |
dc.subject | NANOPARTICLES | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | CHITOSAN | en_US |
dc.subject | CELLS | en_US |
dc.subject | BIODISTRIBUTION | en_US |
dc.subject | PATHOGENESIS | en_US |
dc.subject | INFLAMMATION | en_US |
dc.title | Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors | en_US |
dc.type | Article | en_US |
dc.relation.no | 22608 | - |
dc.relation.volume | 6 | - |
dc.identifier.doi | 10.1038/srep22608 | - |
dc.relation.page | 1-11 | - |
dc.relation.journal | SCIENTIFIC REPORTS | - |
dc.contributor.googleauthor | Kim, Ji Bak | - |
dc.contributor.googleauthor | Park, Kyeongsoon | - |
dc.contributor.googleauthor | Ryu, Jiheun | - |
dc.contributor.googleauthor | Lee, Jae Joong | - |
dc.contributor.googleauthor | Lee, Min Woo | - |
dc.contributor.googleauthor | Cho, Han Saem | - |
dc.contributor.googleauthor | Nam, Hyeong Soo | - |
dc.contributor.googleauthor | Park, Ok Kyu | - |
dc.contributor.googleauthor | Song, Joon Woo | - |
dc.contributor.googleauthor | Yoo, Hongki | - |
dc.relation.code | 2016012537 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | hyoo | - |
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