나무수국 꽃의 Secoiridoid, Iridoid 및 Flavonol 배당체의 골격근세포 비대 유도 효능
- Title
- 나무수국 꽃의 Secoiridoid, Iridoid 및 Flavonol 배당체의 골격근세포 비대 유도 효능
- Other Titles
- Secoiridoids, Iridoids and Flavonol Glycosides from Hydrangea paniculata Flowers and their C2C12 Myotube Hypertrophic Activity
- Author
- 김철영
- Keywords
- Hydrangea paniculata Siebold;; Secoiridoids; Iridoids; Flavonol glycosides; C2C12 myotube hypertrophy
- Issue Date
- 2022-06
- Publisher
- 한국생약학회
- Citation
- 생약학회지(Korean Journal of Pharmacognosy), v. 53, no 2, page. 57-63
- Abstract
- Five secoiridoids (1-3, 5, 10), a iridoid (4) three flavonol glycosides (7-9) and a coumarin (6), were isolated from the flowers of Hydrangea paniculata. Their chemical structures were elucidated as kingiside (1), morroniside (2), sweroside (3), loganin (4), vogeloside (5), umbelliferone (6), quercetin-3-O-sambubioside (7), quercetin-3-O-neohesperidoside (8), kaempferol 3-O-sambubioside (9) and secologanin dimethyl acetal (10), respectively, by spectroscopic analysis. All isolated compounds 1-10 were assessed for their ability to induce C2C12 myotube hypertrophy. Among them, loganin (4) and kaempferol 3-O-sambubioside (9) increase the diameter of C2C12 myotubes. All isolated compounds 1-10 were firstly reported from the flowers of Hydrangea paniculata, and the skeletal muscle hypertrophic activity of 4 and 9 was also reported for the first time.
- URI
- https://scienceon.kisti.re.kr/srch/selectPORSrchArticle.do?cn=JAKO202219353175213&SITE=CLICKhttps://repository.hanyang.ac.kr/handle/20.500.11754/191663
- ISSN
- 0253-3073; 2288-9299
- DOI
- https://doi.org/10.22889/KJP.2022.53.2.57
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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