Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.
- Title
- Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.
- Author
- 유혜현
- Keywords
- Poria cocos; Morus alba L.; Pharmacokinetics; Herb-dug interaction
- Issue Date
- 2024-01-24
- Publisher
- SPRINGERNATURE
- Citation
- JOURNAL OF PHARMACEUTICAL INVESTIGATION, v. 54, no 3, page. 375-387
- Abstract
- Purpose Poria cocos and Morus alba L., recognized as traditional Chinese medicines (TCMs), have gained attention for their diverse pharmacological effects. An herbal extract mixture (named as NB-02) combining these two botanicals has been developed for the prevention and treatment of Alzheimer's disease (AD). To ensure the efficacy and safety of NB-02, we aimed to evaluate the pharmacokinetic profile and herb-drug interaction potential of the major bioactive compounds, poricoic acid A (PAA) and quinic acid (QA), in NB-02.Methods The plasma concentration profiles of PAA and QA were assessed in rats following oral administration of the extract mixture while evaluating the dose and sex-related pharmacokinetic characteristics. Also, potential herb-drug interactions of the extract mixture were evaluated through cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT) inhibition assays. P-glycoprotein (P-gp) substrate and inhibitor prediction was conducted in silico.Results A pharmacokinetic study revealed a dose-dependent increase in plasma levels of PAA and QA. PAA exhibited no sex-specificity, whereas QA demonstrated elevated plasma levels in female rats. Furthermore, NB-02 showed no significant inhibitory effects on the activities of both CYP and UGT enzymes. Also, PAA and QA were predicted to be P-gp non-inhibitors.Conclusion The investigation of the pharmacokinetic properties and herb-drug interactions of the major bioactive compounds, PAA and QA, would provide valuable insights into the pharmacological effects and potential clinical application of NB-02.
- URI
- https://link.springer.com/article/10.1007/s40005-023-00658-3https://repository.hanyang.ac.kr/handle/20.500.11754/191264
- ISSN
- 2093-5552; 2093-6214
- DOI
- https://doi.org/10.1007/s40005-023-00658-3
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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