Potent of strategic approaches for tauopathies ranging from single cell transcriptome to microbiome.

Abstract

Tauopathies as one of the typical neurodegenerative diseases are characterized by pathologicallyaggregated tau in neuron and glia, which causes dysfunction, synapse loss, and cognitiveimpairments. There are more than 26 cases that are classified according to major tau isoformaggregates production or abnormal tau generation processes. Although the various concepts fortargeting tau mechanisms have been investigated, the obvious limitations still remain andconsequently, hindering their applicability. Therefore, additional strategies are required in thetherapeutics and diagnosis. Here, we briefly summarized the etiological tau in thehyperphosphorylation, and the present concepts of tau-targeted disease therapies and diagnosis.We suggest the potential of approaches from deep learning-based single-cell transcriptome tomicrobiome and discuss the encountered challenges for the applicability and practicality.