Developmentofsingle-moleculesensingmethodusingspectrallyresolvedsuper-resolutionmicroscopy
- Title
- Developmentofsingle-moleculesensingmethodusingspectrallyresolvedsuper-resolutionmicroscopy
- Author
- 김근호
- Alternative Author(s)
- 김근호
- Advisor(s)
- 김두리
- Issue Date
- 2021.2
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- Recentadvancesinsingle-moleculespectroscopicimagingtechniques,suchasspectrallyresolvedstochasticopticalreconstructionmicroscopy(SR-STORM),havebeeneffectiveforobtainingdetailedspectralinformationatthemolecularlevel.However,itsapplicationforsingle-moleculesensingishighlychallengingowingtoitscomplicatedconfigurationandlimitedspectralinformation.Inthisstudy,wedemonstratedsingle-moleculepolaritysensingbycombininggrating-basedSR-STORMwiththesolvatochromicdye,Nilered.Thespatialandspectralresolutionsofthecustom-builtgrating-basedSR-STORMwereexaminedforvariouscolorrangesoffluorescentdyes,andthisapproachwassuccessfullyappliedforsensingnanoscalelocalpolarityofvariousorganicsolventmoleculesandsurfactantmolecules.Furthermore,wedemonstratedthattheproposedmethodeffectivelydistinguishedthedifferentpolaritiesoffunctionalgroupswithinsurfactantmoleculesatthesingle-moleculelevel.Weanticipatethattheproposedapproachcanbecombinedwithotherchromicmoleculesforapplicationtomanyotherchemicalsystems.
- URI
- http://hanyang.dcollection.net/common/orgView/200000485467https://repository.hanyang.ac.kr/handle/20.500.11754/188231
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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