Neuroprotective Potential of Carnosine in Cerebrovascular Diseases
- Title
- Neuroprotective Potential of Carnosine in Cerebrovascular Diseases
- Author
- 배옥남
- Keywords
- Carnosine; Ischemic stroke; Hemorrhagic stroke; Vascular dementia; Neuroprotection
- Issue Date
- 2022-01
- Publisher
- SPRINGER
- Citation
- INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, v. 28, NO. 1, article no. 29,
- Abstract
- The growing prevalence, the risk of disabilities, and the lack of effective causal or disease-modifying therapies make cerebrovascular disorders a serious burden. Carnosine, an evolutionarily conserved endogenous dipeptide and over-the-counter food supplement, has a wealth of evidence exhibiting potentially neuroprotective effects. It is a natural, multi-functional, non-toxic anti-glycating antioxidant found in high concentrations in human and mammalian muscle and brain tissues. The physiological presence of carnosine in the brain, ability to cross the blood-brain barrier, and evidence from in vitro, and in vivo studies all point to it as a promising neurotherapeutic agent for cerebrovascular disorders. This review is intended to provide a detailed overview of the neuroprotective role of carnosine in cerebrovascular diseases and summarize existing evidence from cell and animal studies.
- URI
- https://link.springer.com/article/10.1007/s10989-021-10342-5https://repository.hanyang.ac.kr/handle/20.500.11754/182354
- ISSN
- 1573-3149;1573-3904
- DOI
- 10.1007/s10989-021-10342-5
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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