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Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

Title
Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition
Author
임형신
Issue Date
2019-06
Publisher
HINDAWI LTD
Citation
JOURNAL OF ONCOLOGY, v. 2019, article no. 5810465, Page. 1.0-12.0
Abstract
Epithelial-to-mesenchymal transition (EMT) is the first step in the development of the invasive and migratory properties of cancer metastasis. Since the transcriptional reprogramming of a number of genes occurs in EMT, the regulation of EMT transcription factors has been intensively investigated. EMT transcriptional factors are commonly classified by the direct or indirect repression of E-cadherin because one of hallmarks of EMT is the loss of E-cadherin. This facilitates the expression of genes for EMT, tumor invasion, and metastasis. The posttranslational modification of EMT transcriptional factors, such as Snail and Slug, directly regulates their functions, including their stability, nuclear localization, protein-protein interaction, and ubiquitination for the promotion or termination of EMT at the specific points. Here, we discuss how posttranslational modifications regulate gene expression in a dynamic and reversible manner by modifying upstream signaling pathways, focusing in particular on the posttranslational modifications of Snail, Slug, ZEB1, ZEB2, and TWIST1. This review demonstrates that EMT transcription factors regulate metastasis through their posttranslational modifications and that the flexibility and reversibility of EMT can be modified by phosphorylation.
URI
https://www.hindawi.com/journals/jo/2019/5810465/https://repository.hanyang.ac.kr/handle/20.500.11754/180557
ISSN
1687-8450;1687-8469
DOI
10.1155/2019/5810465
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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