RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016)
- Title
- RETRACTED: The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016)
- Author
- 남태규
- Keywords
- aminopyridinol compound BJ-1201; neuroprotection; aminopyridinol HT22; heme oxygenase-1; nuclear transcription factor erythroid-2 related factor 2
- Issue Date
- 2016-05
- Publisher
- MDPI AG
- Citation
- MOLECULES, v. 21.0, NO. 5, article no. 594, Page. 1-11
- Abstract
- Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed that BJ-1201 can protect HT22 cells against glutamate-induced cell cytotoxicity. In addition, BJ-1201 upregulated heme oxygenase-1 (HO-1) to levels comparable to those of the CoPP-treated group. BJ-1201 treatment induced phosphorylation of JNK, but not p38-MAPK or ERK. It also increased the signal in the reporter assay based on beta-galactosidase activity driven by the nuclear transcription factor erythroid-2 related factor 2 (Nrf2) promoter harboring antioxidant response elements (AREs) and induced the translocation of Nrf2. These results demonstrate that BJ-1201 may be a good therapeutic platform against neurodegenerative diseases induced by oxidative stress.
- URI
- https://www.mdpi.com/1420-3049/21/5/594https://repository.hanyang.ac.kr/handle/20.500.11754/179306
- ISSN
- 1420-3049
- DOI
- 10.3390/molecules21050594
- Appears in Collections:
- COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
- Files in This Item:
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