Polypeptide-Based K+Ionophore as a Strong Immunogenic Cell Death Inducer for Cancer Immunotherapy
- Title
- Polypeptide-Based K+Ionophore as a Strong Immunogenic Cell Death Inducer for Cancer Immunotherapy
- Author
- 윤채옥
- Keywords
- DAMP release; dendritic cell maturation; ER stress; immunogenic cell death; potassium ion efflux
- Issue Date
- 2021-12
- Publisher
- American Chemical Society
- Citation
- ACS Applied Bio Materials, v. 4, NO. 12, Page. 8333-8342
- Abstract
- Immunogenic cell death (ICD) is a key factor for generating antitumor immunity. Endoplasmic reticulum (ER) stress triggers the release of damage-associated molecular patterns (DAMPs), thus inducing immunogenicity. We developed a polypeptide-based K+ ionophore that perturbed ion homeostasis and elicited a prolonged ER stress. The ER stress not only fosters an oxidative environment that activates mitochondria-dependent apoptosis pathways but also drives immune responses by releasing DAMPs. The ionophore suppressed tumor proliferation in vitro and in vivo based on the pro-apoptotic activity and immunogenicity.
- URI
- https://pubs.acs.org/doi/10.1021/acsabm.1c00861https://repository.hanyang.ac.kr/handle/20.500.11754/178119
- ISSN
- 2576-6422
- DOI
- 10.1021/acsabm.1c00861
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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