Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2022-12-09T07:00:10Z | - |
dc.date.available | 2022-12-09T07:00:10Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | ACS Applied Bio Materials, v. 4, NO. 12, Page. 8333-8342 | en_US |
dc.identifier.issn | 2576-6422 | en_US |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acsabm.1c00861 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/178119 | - |
dc.description.abstract | Immunogenic cell death (ICD) is a key factor for generating antitumor immunity. Endoplasmic reticulum (ER) stress triggers the release of damage-associated molecular patterns (DAMPs), thus inducing immunogenicity. We developed a polypeptide-based K+ ionophore that perturbed ion homeostasis and elicited a prolonged ER stress. The ER stress not only fosters an oxidative environment that activates mitochondria-dependent apoptosis pathways but also drives immune responses by releasing DAMPs. The ionophore suppressed tumor proliferation in vitro and in vivo based on the pro-apoptotic activity and immunogenicity. | en_US |
dc.description.sponsorship | This work was supported by National Research Foundation of Korea (NRF) grants funded by the Korea government (NRF-2019R1A4A1024116, NRF-2019R1A2C2085962, and NRF-2018M3A9E2024583). | en_US |
dc.language | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.subject | DAMP release | en_US |
dc.subject | dendritic cell maturation | en_US |
dc.subject | ER stress | en_US |
dc.subject | immunogenic cell death | en_US |
dc.subject | potassium ion efflux | en_US |
dc.title | Polypeptide-Based K+Ionophore as a Strong Immunogenic Cell Death Inducer for Cancer Immunotherapy | en_US |
dc.type | Article | en_US |
dc.relation.no | 12 | - |
dc.relation.volume | 4 | - |
dc.identifier.doi | 10.1021/acsabm.1c00861 | en_US |
dc.relation.page | 8333-8342 | - |
dc.relation.journal | ACS Applied Bio Materials | - |
dc.contributor.googleauthor | Lee, DaeYong | - |
dc.contributor.googleauthor | Ha, JongHoon | - |
dc.contributor.googleauthor | Ahn, Hyomin | - |
dc.contributor.googleauthor | Jeong, Seong Dong | - |
dc.contributor.googleauthor | Jeong, MoonKyoung | - |
dc.contributor.googleauthor | Park, Ji-Ho | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kim, Yeu-Chun | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 생명공학과 | - |
dc.identifier.pid | chaeok | - |
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