The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response
- Title
- The insect somatostatin pathway gates vitellogenesis progression during reproductive maturation and the post-mating response
- Author
- 김안모
- Issue Date
- 2022-02
- Publisher
- NATURE PORTFOLIO
- Citation
- NATURE COMMUNICATIONS, v. 13, NO. 1, article no. 969, Page. 1-15
- Abstract
- In mammals, somatostatin plays a role in preventing the release of sex hormones before puberty begins. A Drosophila study uncovered the process by which insect somatostatin controls ovarian development in response to developmental and mating signals. Vitellogenesis (yolk accumulation) begins upon eclosion and continues through the process of sexual maturation. Upon reaching sexual maturity, vitellogenesis is placed on hold until it is induced again by mating. However, the mechanisms that gate vitellogenesis in response to developmental and reproductive signals remain unclear. Here, we have identified the neuropeptide allatostatin-C (AstC)-producing neurons that gate both the initiation of vitellogenesis that occurs post-eclosion and its re-initiation post-mating. During sexual maturation, the AstC neurons receive excitatory inputs from Sex Peptide Abdominal Ganglion (SAG) neurons. In mature virgin females, high sustained activity of SAG neurons shuts off vitellogenesis via continuous activation of the AstC neurons. Upon mating, however, Sex Peptide inhibits SAG neurons, leading to deactivation of the AstC neurons. As a result, this permits both JH biosynthesis and the progression of vitellogenesis in mated females. Our work has uncovered a central neural circuit that gates the progression of oogenesis.
- URI
- https://www.nature.com/articles/s41467-022-28592-2https://repository.hanyang.ac.kr/handle/20.500.11754/178009
- ISSN
- 2041-1723;2041-1723
- DOI
- 10.1038/s41467-022-28592-2
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
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