Etamycin as a NovelMycobacterium abscessusInhibitor
- Title
- Etamycin as a NovelMycobacterium abscessusInhibitor
- Author
- 양철수
- Keywords
- Mycobacterium abscessus; drug resistance; novel drug discovery
- Issue Date
- 2020-09
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Citation
- International Journal of Molecular Sciences, v. 21.0, NO. 18, article no. 6908, Page. 1-14
- Abstract
- The increase in drug-resistantMycobacterium abscessus, which has become resistant to existing standard-of-care agents, is a major concern, and new antibacterial agents are strongly needed. In this study, we introduced etamycin that showed an excellent activity againstM. abscessus. We found that etamycin significantly inhibited the growth ofM. abscessuswild-type strain, three subspecies, and clinical isolates in vitro and inhibited the growth ofM. abscessusthat resides in macrophages without cytotoxicity. Furthermore, the in vivo efficacy of etamycin in the zebrafish (Danio rerio) infection model was greater than that of clarithromycin, which is recommended as the core agent for treatingM. abscessusinfections. Thus, we concluded that etamycin is a potential anti-M. abscessuscandidate for further development as a clinical drug candidate.
- URI
- https://www.mdpi.com/1422-0067/21/18/6908https://repository.hanyang.ac.kr/handle/20.500.11754/177543
- ISSN
- 1661-6596;1422-0067
- DOI
- 10.3390/ijms21186908
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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- 426_양철수.pdfDownload
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