Biodegradable silicon nanoneedles for ocular drug delivery
- Title
- Biodegradable silicon nanoneedles for ocular drug delivery
- Author
- 김동립
- Issue Date
- 2022-04
- Publisher
- AMER ASSOC ADVANCEMENT SCIENCE
- Citation
- SCIENCE ADVANCES, v. 8, NO. 13, article no. eabn1772, Page. 1-12
- Abstract
- Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases.
- URI
- https://www.science.org/doi/10.1126/sciadv.abn1772https://repository.hanyang.ac.kr/handle/20.500.11754/177350
- ISSN
- 2375-2548;2375-2548
- DOI
- 10.1126/sciadv.abn1772
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > MECHANICAL ENGINEERING(기계공학부) > Articles
- Files in This Item:
- Biodegradable silicon nanoneedles for ocular drug delivery.pdfDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML