Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김동립 | - |
dc.date.accessioned | 2022-11-24T01:46:14Z | - |
dc.date.available | 2022-11-24T01:46:14Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.citation | SCIENCE ADVANCES, v. 8, NO. 13, article no. eabn1772, Page. 1-12 | en_US |
dc.identifier.issn | 2375-2548;2375-2548 | en_US |
dc.identifier.uri | https://www.science.org/doi/10.1126/sciadv.abn1772 | en_US |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/177350 | - |
dc.description.abstract | Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases. | en_US |
dc.description.sponsorship | C.H.L. and Y.M.P. acknowledge funding support from the NIH National Eye Institute (NEI) (award number R01EY033000). C.H.L. also acknowledges the National Science Foundation (NSF) Chemical, Bioengineering, Environment, and Transport Systems (CBET) (award number 2032529). Y.M.P. also acknowledges the funding support from the NIH NEI (award numbers 1K08EY027458 and 1R41EY031219) along with the unrestricted departmental support from Research to Prevent Blindness. This work used the Vision Research Core Center funded by P30EY007003 from the NEI. D.R.K. acknowledges the funding support from the International Research and Development Program (NRF-2018K1A3A1A32055469) through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT of Korea. Y.J. acknowledges the funding support from the MOTIE (Ministry of Trade, Industry, and Energy) in Korea, under the Fostering Global Talents for Innovative Growth Program (P0008748, Global Human Resource Development for Innovative Design in Robot and Engineering) supervised by the Korea Institute for Advancement of Technology (KIAT). | en_US |
dc.language | en | en_US |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | en_US |
dc.title | Biodegradable silicon nanoneedles for ocular drug delivery | en_US |
dc.type | Article | en_US |
dc.relation.no | 13 | - |
dc.relation.volume | 8 | - |
dc.identifier.doi | 10.1126/sciadv.abn1772 | en_US |
dc.relation.page | 1-12 | - |
dc.relation.journal | SCIENCE ADVANCES | - |
dc.contributor.googleauthor | Park, Woohyun | - |
dc.contributor.googleauthor | Nguyen, Van Phuc | - |
dc.contributor.googleauthor | Jeon, Yale | - |
dc.contributor.googleauthor | Kim, Bongjoong | - |
dc.contributor.googleauthor | Li, Yanxiu | - |
dc.contributor.googleauthor | Yi, Jonghun | - |
dc.contributor.googleauthor | Kim, Hyungjun | - |
dc.contributor.googleauthor | Leem, Jung Woo | - |
dc.contributor.googleauthor | Kim, Young L. | - |
dc.contributor.googleauthor | Kim, Dong Rip | - |
dc.contributor.googleauthor | Paulus, Yannis M. | - |
dc.contributor.googleauthor | Lee, Chi Hwan | - |
dc.sector.campus | S | - |
dc.sector.daehak | 공과대학 | - |
dc.sector.department | 기계공학부 | - |
dc.identifier.pid | dongrip | - |
dc.identifier.orcid | https://orcid.org/0000-0001-6398-9483 | - |
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