Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods
- Title
- Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods
- Author
- 김종호
- Keywords
- Europium hydroxide [Eu-III(OH)(3)] nanorods; reactive oxygen species; hydrogen peroxide (H2O2); single-walled carbon nanotubes; in vivo angiogenesis; zebrafish model
- Issue Date
- 2011-11
- Publisher
- American Chemical Society
- Citation
- Nano Letters, v. 11, NO. 11, Page. 4932-4938
- Abstract
- The exact mechanism of angiogenesis by europium hydroxide nanorods was unclear. In this study we have showed that formation of reactive oxygen species (H2O2 and O-2 center dot-) is involved in redox signaling pathways during angiogenesis, important for cardiovascular and ischemic diseases. Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O-2 center dot- from endothelial cells in response to proangiogenic factors. Additionally, reactive oxygen species-mediated angiogenesis using inorganic nanorods was observed in transgenic (flila:EGFP) zebrafish embryos.
- URI
- https://pubs.acs.org/doi/10.1021/nl2028766https://repository.hanyang.ac.kr/handle/20.500.11754/175987
- ISSN
- 1530-6984;1530-6992
- DOI
- 10.1021/nl2028766
- Appears in Collections:
- COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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