Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study
- Title
- Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study
- Author
- 박은정
- Keywords
- metabolic syndrome; colorectal cancer; propensity score methods; cohort
- Issue Date
- 2020-11
- Publisher
- MDPI
- Citation
- INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 17, no. 22, article no. 8687, page. 1-11
- Abstract
- Background: This study aimed to determine the effects of metabolic syndrome (MetS) on colorectal cancer (CRC) using propensity score (PS) methods. Methods: The study subjects were 2417 men and 4568 women from the Korean National Cancer Center (KNCC) Community Cohort enrolled between 2003 and 2010. Odds risks (ORs) and 95% confidence intervals (CIs) using PS matching analysis, regression models adjusted by the PS or stratified into five strata according to PS, and PS weighting methods were calculated. Results: In women, MetS and abnormally high triglyceride (TG) levels were associated with CRC risk using the PS matching analysis (ORs, for MetS, 2.19 (95% CI, 1.10–4.33); for abnormal TG levels, 2.08 (95% CI, 1.07–4.02)). However, there were no significant associations between MetS and TG levels and CRC risk in men. Conclusions: Our study might provide additional evidence that deteriorated metabolic profiles increase the risk of CRC in women rather than men. Thus, this may have an important role in effective population-level interventions for deteriorated metabolic profiles at an early stage.
- URI
- https://www.mdpi.com/1660-4601/17/22/8687https://repository.hanyang.ac.kr/handle/20.500.11754/172613
- ISSN
- 1660-4601
- DOI
- 10.3390/ijerph17228687
- Appears in Collections:
- RESEARCH INSTITUTE[S](부설연구소) > ETC
- Files in This Item:
- Metabolic Syndrome and Colorectal Cancer Risk Results of Propensity Score-Based Analyses in a Community-Based Cohort Study.pdfDownload
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