인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향
- Title
- 인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향
- Other Titles
- Impact on Quality of Life after Treatment with Proton Pump Inhibitor in Laryngopharyngeal Reflux
- Author
- 태경
- Keywords
- Laryngopharyngeal reflux; Laryngoscopy; Proton pump inhibitor; Quality of life
- Issue Date
- 2020-11
- Publisher
- 대한이비인후과학회
- Citation
- Korean Journal of Otorhinolaryngology- Head and Neck Surgery, v. 63, no. 11, page. 517-522
- Abstract
- Background and Objectives: Several studies have assessed the impact of laryngopharyngealreflux disease (LPRD) on the health-related quality of life (HR-QoL), showing significantimpairment of HR-QoL. This study aims to assess the impact of proton pump inhibitor (PPI)treatment of LPRDs to enhance HR-QoL.
Subjects and Method: We prospectively collected data from LPRD patients from April2017 to July 2019. Patients who have reflux symptom index (RSI) of ≥13 or reflux findingscore (RFS) of ≥7 were enrolled in this study. We assessed HR-QoL using a questionnairewith EORTC QLQ-H&N35, -C30 on the first visit. Patients were treated with PPI (Ilaprazole20 mg/day) on their visits at 4, 8, and 12 weeks. RSI and RFS were measured at each visit andHR-QoL was reevaluated on the last visit.
Results: Ninety-five patients completed the 3-months follow-up and were enrolled in thisstudy. Female : male ratio was 71:24 and the mean age was 57.0±11.9 (27-80). The initial RSIand RFS were 16.3±8.8 and 12.6±2.9, respectively, but were changed to 11.1±9.7 and 9.7±2.6(p˂0.001 in both) at 12 weeks after the treatment. Global health status/QoL, speech problem,dry mouth, and coughing were significantly improved.
Conclusion: PPI administration is effective in treating LPRD, where effects begin to appear at4 weeks after treatment. HR-QoL was also improved in patients who have RSI improvement.
- URI
- https://www.kjorl.org/journal/view.php?doi=10.3342/kjorl-hns.2019.00899https://repository.hanyang.ac.kr/handle/20.500.11754/172099
- ISSN
- 2092-6529
- DOI
- 10.3342/kjorl-hns.2019.00899
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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