인후두 역류질환에서 양성자 펌프 억제제 치료가 삶의 질에 미치는 영향

Abstract

Background and Objectives: Several studies have assessed the impact of laryngopharyngealreflux disease (LPRD) on the health-related quality of life (HR-QoL), showing significantimpairment of HR-QoL. This study aims to assess the impact of proton pump inhibitor (PPI)treatment of LPRDs to enhance HR-QoL. Subjects and Method: We prospectively collected data from LPRD patients from April2017 to July 2019. Patients who have reflux symptom index (RSI) of ≥13 or reflux findingscore (RFS) of ≥7 were enrolled in this study. We assessed HR-QoL using a questionnairewith EORTC QLQ-H&N35, -C30 on the first visit. Patients were treated with PPI (Ilaprazole20 mg/day) on their visits at 4, 8, and 12 weeks. RSI and RFS were measured at each visit andHR-QoL was reevaluated on the last visit. Results: Ninety-five patients completed the 3-months follow-up and were enrolled in thisstudy. Female : male ratio was 71:24 and the mean age was 57.0±11.9 (27-80). The initial RSIand RFS were 16.3±8.8 and 12.6±2.9, respectively, but were changed to 11.1±9.7 and 9.7±2.6(p˂0.001 in both) at 12 weeks after the treatment. Global health status/QoL, speech problem,dry mouth, and coughing were significantly improved. Conclusion: PPI administration is effective in treating LPRD, where effects begin to appear at4 weeks after treatment. HR-QoL was also improved in patients who have RSI improvement.