In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis.
- Title
- In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis.
- Author
- 김기현
- Keywords
- Neisseria meningitidis; vaccine development; epidemic disease; immunogenicity
- Issue Date
- 2020-10
- Publisher
- MDPI
- Citation
- APPLIED SCIENCES-BASEL, v. 10, no. 17, article no. 6113
- Abstract
- Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo.
- URI
- https://www.mdpi.com/2076-3417/10/17/6113https://repository.hanyang.ac.kr/handle/20.500.11754/171264
- ISSN
- 2076-3417
- DOI
- 10.3390/app10176113
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > CIVIL AND ENVIRONMENTAL ENGINEERING(건설환경공학과) > Articles
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- In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis..pdfDownload
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