Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기현 | - |
dc.date.accessioned | 2022-05-31T08:04:13Z | - |
dc.date.available | 2022-05-31T08:04:13Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.citation | APPLIED SCIENCES-BASEL, v. 10, no. 17, article no. 6113 | en_US |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://www.mdpi.com/2076-3417/10/17/6113 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/171264 | - |
dc.description.abstract | Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general treatment strategies) to treat this emerging pathogen. Iron is a crucial transition metal for N. meningitidis. Proteomic analysis data could be valuable for vaccine design. Here, we conduct a comparative study using computational bioinformatic tools to identify the most effective iron-regulated outer membrane proteins (OMPs) as immunogenic targets for a potential vaccine against N. meningitidis. The basic properties of N. meningitidis OMPs are explored for flexibility, solubility, hydrophilicity, beta-turns, and overall antigenic probability. Results of our study suggest that iron-regulated OMPs are flexible and soluble in water with high densities of conformational B-cell epitopes. As such, they can be recommended as a novel candidate for a vaccine against N. meningitidis both in vitro and in vivo. | en_US |
dc.description.sponsorship | This research is partially funded by National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (Grant No: 2016R1E1A1A01940995). | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.subject | Neisseria meningitidis | en_US |
dc.subject | vaccine development | en_US |
dc.subject | epidemic disease | en_US |
dc.subject | immunogenicity | en_US |
dc.title | In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis. | en_US |
dc.type | Article | en_US |
dc.relation.volume | 10 | - |
dc.identifier.doi | 10.3390/app10176113 | - |
dc.relation.page | 1-12 | - |
dc.relation.journal | APPLIED SCIENCES-BASEL | - |
dc.contributor.googleauthor | Rahman, Md. Shahedur | - |
dc.contributor.googleauthor | Biswas, Chayon | - |
dc.contributor.googleauthor | Biswas, Polash Kumar | - |
dc.contributor.googleauthor | Kader, Md. Ashraful | - |
dc.contributor.googleauthor | Alam, S. M. Nur | - |
dc.contributor.googleauthor | Sonne, Christian | - |
dc.contributor.googleauthor | Kim, Ki-Hyun | - |
dc.relation.code | 2020047168 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING | - |
dc.identifier.pid | kkim61 | - |
dc.identifier.orcid | https://orcid.org/0000-0003-0487-4242 | - |
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