Blood Oxygenation Using Fluoropolymer-Based Artificial Lung Membranes

Title
Blood Oxygenation Using Fluoropolymer-Based Artificial Lung Membranes
Author
이영무
Keywords
artificial lung; blood oxygenation; hemocompatibility; fluoropolymers; extracorporeal membrane oxygenators
Issue Date
2020-10
Publisher
AMER CHEMICAL SOC
Citation
ACS BIOMATERIALS SCIENCE & ENGINEERING, v. 6, no. 11, page. 6424-6434
Abstract
Artificial lung (AL) membranes are used for blood oxygenation for patients undergoing open-heart surgery or acute lung failures. Current AL technology employs polypropylene and polymethylpentene membranes. Although effective, these mem-branes suffer from low biocompatibility, leading to undesired blood coagulation and hemolysis over a long term. In this work, we propose a new generation of AL membranes based on amphiphobic fluoropolymers. We employed poly(vinylidene-co-hexafluoropropylene), or PVDF-co-HFP, to fabricate macrovoid-free membranes with an optimal pore size range of 30-S0 nm. The phase inversion behavior of PVDF-co-HFP was investigated in detail for structural optimization. To improve the wetting stability of the membranes, the fabricated membranes were coated using Hyflon AD60X, a type of fluoropolymer with an extremely low surface energy. Hyflon-coated materials displayed very low protein adsorption and a high contact angle for both water and blood. In the hydrophobic spectrum, the data showed an inverse relationship between the surface free energy and protein adsorption, suggesting an appropriate direction with respect to biocompatibility for AL research. The blood oxygenation performance was assessed using animal sheep blood, and the fabricated fluoropolymer membranes showed competitive performance to that of commercial polyolefin membranes without any detectable hemolysis. The data also confirmed that the bottleneck in the blood oxygenation performance was not the membrane permeance but rather the rate of mass transfer in the blood phase, highlighting the importance of efficient module design.
URI
https://pubs.acs.org/doi/10.1021/acsbiomaterials.0c01251https://repository.hanyang.ac.kr/handle/20.500.11754/171146
ISSN
2373-9878
DOI
10.1021/acsbiomaterials.0c01251
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ENERGY ENGINEERING(에너지공학과) > Articles
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