Noise-induced hearing loss in zebrafish model: Characterization of tonotopy and sex-based differences
- Title
- Noise-induced hearing loss in zebrafish model: Characterization of tonotopy and sex-based differences
- Author
- 최지웅
- Keywords
- Noise; Sound frequency; Zebrafish; Hearing loss; Sex
- Issue Date
- 2022-03
- Publisher
- ELSEVIER
- Citation
- HEARING RESEARCH, v. 418, NO 108485, Page. 1-14
- Abstract
- Hearing loss caused by frequent and persistent exposure to loud noise is one of the most common dis-
eases in modern society. Many studies have demonstrated the characteristics of noise-induced hearing
loss in human and non-human vertebrate models, including frequency-specific noise-induced hearing loss
and sex-biased differences. Zebrafish (Danio rerio) is a useful hearing research model because its lateral
line is easy to access and because of its detailed perception of sound. Despite the increasing popularity
of zebrafish as a model for NIHL, a better understanding of this model is needed to determine sex dif-
ferences in NIHL. To study the features of zebrafish as they relate to an NIHL model, we tested various
phenotypes after frequency-specific noise stimulation. The degree of damage to hair cells and hearing loss
were investigated after exposing zebrafish to 200 Hz and 1 kHz continuous waves and broadband white
noise with a bandwidth from 50 Hz to 1 kHz. After exposure to all frequencies, the larvae showed lateral
line hair cell damage, which is superficially located. In adult zebrafish, the threshold of auditory-evoked
potential signals is elevated. Moreover, the number of hair cells remarkably decreased in the rostral re-
gion of the saccule, after exposure to 1 kHz and white noise, whereas zebrafish exposed to 200 Hz noise
showed a decrease in hair cells in the caudal region. Moreover, male zebrafish were found to be more
vulnerable to noise than female zebrafish, as is the case in humans and other mammals. Cortisol levels
also increased in the noise-exposed male group, as compared to the noise-exposed female and control
male groups. However, there was no difference in cortisol levels when the noise-exposed female group
was compared to the control female group. Our study demonstrates not only that noise-induced hear-
ing loss is frequency-dependent but also that the degree of hearing loss is affected by sex in zebrafish,
emphasizing the need to consider sex in NIHL studies.
- URI
- https://www.sciencedirect.com/science/article/pii/S0378595522000569https://repository.hanyang.ac.kr/handle/20.500.11754/170800
- ISSN
- 0378-5955
- DOI
- 10.1016/j.heares.2022.108485
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
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