Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance
- Title
- Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance
- Author
- 유승준
- Keywords
- AMPK; autophagy; energy balance; energy expenditure; food intake; hypothalamus; lipid metabolism; lipophagy; tanycyte; TSPO
- Issue Date
- 2020-07
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- AUTOPHAGY, v. 16, no. 7, page. 1200-1220
- Abstract
- Hypothalamic glial cells named tanycytes, which line the 3(rd) ventricle (3V), are components of the hypothalamic network that regulates a diverse array of metabolic functions for energy homeostasis. Herein, we report that TSPO (translocator protein), an outer mitochondrial protein, is highly enriched in tanycytes and regulates homeostatic responses to nutrient excess as a potential target for an effective intervention in obesity. Administration of a TSPO ligand, PK11195, into the 3V, and tanycyte-specific deletion of Tspo reduced food intake and elevated energy expenditure, leading to negative energy balance in a high-fat diet challenge. Ablation of tanycytic Tspo elicited AMPK-dependent lipophagy, breaking down lipid droplets into free fatty acids, thereby elevating ATP in a lipid stimulus. Our findings suggest that tanycytic TSPO affects systemic energy balance through macroautophagy/autophagy-regulated lipid metabolism, and highlight the physiological significance of TSPO in hypothalamic lipid sensing and bioenergetics in response to overnutrition.
- URI
- https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1659616https://repository.hanyang.ac.kr/handle/20.500.11754/169326
- ISSN
- 1554-8627; 1554-8635
- DOI
- 10.1080/15548627.2019.1659616
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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