Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression
- Title
- Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression
- Author
- 안성훈
- Issue Date
- 2021-05
- Publisher
- MDPI
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, Issue. 10, Article no. 5398, 16pp
- Abstract
- Depression is a highly prevalent, disabling, and often chronic illness that places substantial burdens on patients, families, healthcare systems, and the economy. A substantial minority of patients are unresponsive to current therapies, so there is an urgent need to develop more broadly effective, accessible, and tolerable therapies. Pharmacological regulation of histone acetylation level has been investigated as one potential clinical strategy. Histone acetylation status is considered a potential diagnostic biomarker for depression, while inhibitors of histone deacetylases (HDACs) have garnered interest as novel therapeutics. This review describes recent advances in our knowledge of histone acetylation status in depression and the therapeutic potential of HDAC inhibitors.
- URI
- https://www.proquest.com/docview/2532581560?accountid=11283https://repository.hanyang.ac.kr/handle/20.500.11754/166760
- ISSN
- 1422-0067
- DOI
- 10.3390/ijms22105398
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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