Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease
- Title
- Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease
- Author
- 김희태
- Keywords
- Impulse control disorder; Parkinson’s disease; Dopamine agonist; Neuropsychiatric traits; Obsessive compulsiveness
- Issue Date
- 2020-05
- Publisher
- KARGER
- Citation
- NEURODEGENERATIVE DISEASES, v. 19, no. 5-6, page. 171-177
- Abstract
- Introduction:Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD.Objective:This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD.Methods:We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis.Results:The poor-outcome group showed higher levels of anger expression (p =0.007) and obsessive-compulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group.Conclusions:Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD.
- URI
- https://www.karger.com/Article/FullText/507447https://repository.hanyang.ac.kr/handle/20.500.11754/166248
- ISSN
- 1660-2862; 1660-2854
- DOI
- 10.1159/000507447
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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