Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김희태 | - |
dc.date.accessioned | 2021-11-15T07:43:52Z | - |
dc.date.available | 2021-11-15T07:43:52Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.citation | NEURODEGENERATIVE DISEASES, v. 19, no. 5-6, page. 171-177 | en_US |
dc.identifier.issn | 1660-2862 | - |
dc.identifier.issn | 1660-2854 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/507447 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/166248 | - |
dc.description.abstract | Introduction:Impulse control disorder (ICD) in Parkinson's disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD.Objective:This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD.Methods:We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical increases in ICD behaviors after the substitution of dopamine agonists with levodopa. We analyzed the pre-intervention personality traits associated with the poor outcome and also evaluated the risk traits for refractory ICD using a receiver-operating characteristic (ROC) curve analysis.Results:The poor-outcome group showed higher levels of anger expression (p =0.007) and obsessive-compulsive traits (p =0.009) compared with the good-outcome group at the pre-intervention state. In the ROC curve analysis, the Obsessive-Compulsive Inventory showed the highest area under the curve with 80.0% sensitivity and 74.3% specificity in discriminating against the poor-outcome group.Conclusions:Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD. | en_US |
dc.description.sponsorship | This study was funded by Research Grant of Sandos Korea, Ltd. The funder had no role in the design or preparation of the study or manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Impulse control disorder | en_US |
dc.subject | Parkinson’s disease | en_US |
dc.subject | Dopamine agonist | en_US |
dc.subject | Neuropsychiatric traits | en_US |
dc.subject | Obsessive compulsiveness | en_US |
dc.title | Neuropsychiatric Traits Associated with Refractory Impulse Control Disorder in Parkinson's Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 5-6 | - |
dc.relation.volume | 19 | - |
dc.identifier.doi | 10.1159/000507447 | - |
dc.relation.page | 171-177 | - |
dc.relation.journal | NEURODEGENERATIVE DISEASES | - |
dc.contributor.googleauthor | Choi, Ji-Hyun | - |
dc.contributor.googleauthor | Lee, Jee-Young | - |
dc.contributor.googleauthor | Jeon, Beomseok | - |
dc.contributor.googleauthor | Koh, Seong-Beom | - |
dc.contributor.googleauthor | Yoon, Won Tae | - |
dc.contributor.googleauthor | Lee, Ho-Won | - |
dc.contributor.googleauthor | Kwon, Oh Dae | - |
dc.contributor.googleauthor | Kim, Jae Woo | - |
dc.contributor.googleauthor | Kim, Jong-Min | - |
dc.contributor.googleauthor | Kim, Hee Tae | - |
dc.relation.code | 2020046297 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kimht | - |
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