Total Synthesis of Arucadiol and 1-Oxomiltirone with Gold and Copper-catalyzed Cyclization and The Synthetic Approach of [6,6,6]-Tricyclic Abietane Analogues
- Title
- Total Synthesis of Arucadiol and 1-Oxomiltirone with Gold and Copper-catalyzed Cyclization and The Synthetic Approach of [6,6,6]-Tricyclic Abietane Analogues
- Other Titles
- 금과 구리 촉매를 이용한 고리화 반응으로 Arucadiol과 1-Oxomiltirone의 전합성연구와 [6,6,6]-Tricyclic Abietane Analogues 합성 연구
- Author
- 성채현
- Alternative Author(s)
- 성채현
- Advisor(s)
- 오창호
- Issue Date
- 2021. 8
- Publisher
- 한양대학교
- Degree
- Master
- Abstract
- Part 1. Total Synthesis of Arucadiol and 1-Oxomiltirone with Gold and Copper-catalyzed Cyclization
Natural products with many important biological activities are mostly composed of multiple ring compounds. In particular, abietanes are natural product, triple ring compounds, that has been studied and have many biological activities like excellent antibacterial activity. Among them, we effectively synthesized arucadiol and 1-oxomiltirone, which have excellent antibacterial and anticancer properties, through a cyclization reaction with gold and copper catalysts.
Part 2. The Synthetic Approach of [6,6,6]-Tricyclic Abietane Analogue
Cyclization in mamy complicated structures using transition-metal catalysts have been studied for long time. The reaction using transition-metals is considered important synthetic pathways because is able to synthesize selective and effectively. We synthesized several abietane analogues, [6,6,6]-tricyclic compounds, using gold and copper catalysts.
- URI
- http://hanyang.dcollection.net/common/orgView/200000490319https://repository.hanyang.ac.kr/handle/20.500.11754/163729
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > CHEMISTRY(화학과) > Theses (Master)
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