Total Synthesis of Arucadiol and 1-Oxomiltirone with Gold and Copper-catalyzed Cyclization and The Synthetic Approach of [6,6,6]-Tricyclic Abietane Analogues

Abstract

Part 1. Total Synthesis of Arucadiol and 1-Oxomiltirone with Gold and Copper-catalyzed Cyclization Natural products with many important biological activities are mostly composed of multiple ring compounds. In particular, abietanes are natural product, triple ring compounds, that has been studied and have many biological activities like excellent antibacterial activity. Among them, we effectively synthesized arucadiol and 1-oxomiltirone, which have excellent antibacterial and anticancer properties, through a cyclization reaction with gold and copper catalysts.

Part 2. The Synthetic Approach of [6,6,6]-Tricyclic Abietane Analogue Cyclization in mamy complicated structures using transition-metal catalysts have been studied for long time. The reaction using transition-metals is considered important synthetic pathways because is able to synthesize selective and effectively. We synthesized several abietane analogues, [6,6,6]-tricyclic compounds, using gold and copper catalysts.